I've been using H&R Block software for years and I wouldn't use anything else. Easy to use and very detailed. I have a pretty simple tax return each year with only a handful of itemized deductions and I complete my taxes in under 30 minutes every year.
I can sit at my desk, download the program, and do my taxes all without going anywhere. The price is good and any questions I've run into have had easy to get answers. What else do you need ?