Season 1 of the crime drama begins with forensic anthropologist Temperance "Bones" Brennan (Emily Deschanel) back in D.C. after months away identifying genocide victims. Agent Seeley Booth (David Boreanaz) promptly hijacks her to help him with a case. Brennan initially refuses, but her boss at the Jeffersonian Institute, Dr. Daniel Goodman (Jonathan Adams), insists that part of her job is being lent out to the FBI. She agrees to work with Booth, but only if she can be his partner in all areas of the cases. The first of these cases establishes the premise for the next 21 episodes. After a body surfaces, the remains are transferred to the Jeffersonian, where Brennan and her devoted "squints" leap to action. Brennan's team includes her assistant, the socially inept but brilliant Zack Addy (Eric Millegan); bugs and slime expert Dr. Jack Hodgins (T.J. Thyne); and her best friend, forensic artist Angela Montenegro (Michaela Conlin). The main suspect turns out to be a powerful senator, but despite warnings from the FBI to stay away, Brennan continues with her investigation. Throughout the season, Brennan and Booth are devoted to uncovering the truth, repeatedly finding themselves in dangerous situations and relying on each other for backup. Booth eventually confides to Brennan that he wants to bring closure to victims' loved ones to make up for the lives he took in his sniper past. Brennan, meanwhile, is dedicated to identifying the deceased as a result of the mysterious disappearance of her parents years ago. The duo work together to solve crimes involving small-town cannibals, promiscuous private-school teens and a homeless society in an underground tunnel. As each case draws to a close, the bantering pair grow more intimate, a closeness heightened during the season finale, when unearthed bones provide a link to Brennan's past that may reunite her with the family she thought was lost forever.

The fifth season of Bones finds forensic whiz Brennan (Emily Deschanel) and Special Agent Booth (David Boreanaz) tackling more complex cases, and continuing to build the sexual tension between them. This set contains every episode from that season.

The crime drama's fourth season begins with Dr. Temperance Brennan (Emily Deschane) and Seeley Booth (David Boreanaz) lecturing to their respective peers in London, but their trip is extended after they're drawn into the murder of a wealthy American's daughter. Other investigations spin around the slayings of a reality-TV host, a veterinarian, a pastor, a sculptor, a former Marine, conjoined twins, an ice-hockey player and a bride-to-be. Cycle 4 also features the return of the Grave Digger, a sepulchral serial killer who may be targeting Booth.