You can - but these have a 2.5 mm jack. Most cell phones have a 3.5 mm jack so you will need an adapter. We use these in our office for our landline handsets but purchased several adapters online for about 2 bucks each so that people could use them with their cell phones as well. If you don't want to go to bluetooth, I'd say these are a pretty good alternative. I like the way they sound better than most in-line headphone microphones which dangle down by your chest. They also seem to be less susceptible to ambient noise.