During his fourth season, the dyspeptic medical detective (Hugh Laurie) is consumed by his search for a new team of associates to replace Foreman and Cameron (Omar Epps, Jennifer Morrison), who quit on him, and Chase (Jesse Spencer), whom he fired. The winnowing process begins with an unmanageable 40 applicants, so House gives them numbers and behaves like Simon Cowell, MD: firing people arbitrarily (by where they are sitting, at one point) and ordering others to wash his car. Eventually, he narrows the field to Jeffrey Cole (Edi Gathegi), Amber Volakis (Anne Dudek), Chris Taub (Peter Jacobson), Lawrence Kutner (Kal Penn) and "Thirteen" (Olivia Wilde). He also hires a CIA doctor (Michael Michele) who doesn't want the job---only to fire her when she reconsiders. House dismisses Cole and Volakis (also known as "cutthroat bitch") as well, but she doesn't go away. Instead, she starts a relationship with Wilson (Robert Sean Leonard). Meanwhile, House's sexually tense love-hate relationship with Cuddy (Lisa Edelstein) intensifies, and Foreman, Cameron and Chase all return to Princeton/Plainsboro, although only Foreman returns to House's team. And through it all, House continues to perform his unique brand of medicine. In one episode, he diagnoses a psychiatrist (Mira Sorvino) who is stranded in an Antarctic research station via Webcam. And in another he kidnaps an unbelieving soap star (Jason Lewis) after noticing disturbing symptoms while watching him on television.

This set contains all 22 episodes from the final season of the popular medical procedural series House, starring Hugh Laurie as a prickly medical genius solving tricky medical mysteries while fighting personal demons and his own surly attitude.