Yes. It will work in a closet/cabinet anywhere within 30-ish feet of you. I've Installed plenty of these and used them to control equipment in closets. The only thing you have to remember is that the Harmony Hub will be controlling all the items in the closet(via RF signal sent from the handheld remote to the Hub) and the handheld remote will send the signal to the TV itself via a line-of-site IR signal - so you will have to (somewhat) point the remote toward the TV when starting the built in activities (Watch TV, Watch BluRay, etc.)