The seventh and final season of the adaptation of Charlaine Harris' Southern vampire novels begins with a vampire-human mixer at Bellefleur's, née Merlotte's, in full swing, but a gruesome attack by a band of Hep V-infected bloodsuckers throws Bon Temps into chaos and prompts a wave of spiteful finger-pointing at one of its most well-known residents--Sookie (Anna Paquin). Meanwhile, Jessica (Deborah Ann Woll) tries to convince Andy (Chris Bauer) she's desperate to atone for her past mistakes; Bill (Stephen Moyer) recalls his pre-Civil War life; Jason (Ryan Kwanten) has an awkward reunion with an old friend; Lafayette (Nelsan Ellis) helps Lettie Mae (Adina Porter) resolve her tumultuous relationship with Tara (Rutine Wesley); and Pam (Kristin Bauer Van Straten) searches the globe for Eric (Alexander Skarsgård)--assuming he's still alive!

The 10th season of this medical drama finds the doctors trying to care for storm victims, and among the victims is an electrocuted Webber (James Pickens Jr.), who has put Meredith (Ellen Pompeo) in charge of his medical decisions. The hospital itself is damaged in the storm, which results in Owen (Kevin McKidd) and Jackson (Jesse Williams) clashing over finance issues. But they're not the only ones fighting: Callie (Sara Ramirez) and Arizona (Jessica Capshaw) struggle to reconcile in the wake of Arizona's infidelity; and best friends Meredith and Cristina (Sandra Oh) have a falling-out over a work matter. Meanwhile, Meredith also has trouble balancing work and motherhood after she and Derek (Patrick Dempsey) return to work following the birth of their son; and Alex (Justin Chambers) sees his estranged father, who's a drug addict, arrive in the ER as a patient.