Telepath and barmaid Sookie Stackhouse (Anna Paquin) finds herself falling for vampire Bill Compton (Stephen Moyer) despite the warnings of her human companions and the admittedly menacing presence of Bill's decidedly less "mainstream" friends. However, the real threat to Sookie comes in the form of a serial killer who appears to be targeting young women who may have had relationships with vampires in the small town of Bon Temps, LA.