Yes, it absolutely will work for a desktop PC, as long as it has a SATA connection (it would have to be a pretty old PC to not have SATA). You MAY run into an issue with mounting the drive in the desktop tower, but they are very lightweight and very shock resistant, so it isn't a big deal to just let it sit in the tower if you aren't moving the computer around frequently. Or even get some velcro or something. :-)