I'm pretty selective about the paper I use in my home office. I used a ream of the Staples Bright White 20# and liked it a lot. So far the 22# is performing as well as the 20#. (Am I a paper geek or a paper snob?)
I am a teacher and use a great deal of paper with my private students. I use both an injet printer and a copy machine often simultaneously and I need to be able to have the paper I use work for all situations copying printing and especially two-sided printing that doesn't show through to the other side. Purchasing one case at a time offers me a huge savings which I can then spend on other needed supplies. The word "multi-purpose" says it all.