It took some getting used to, but it's fine. The clicking is easy and quiet. The scroll wheel is nice. The thumb side is a little awkward and cramps my hand, but it's ok now. Maybe I'm not holding it properly, but there aren't any instructions that show how I'm supposed to hold it. I have tiny hands. I can't imagine how someone with big hands would handle it.
I work on my computer for my employment. I have to say, not hearing the constant clicking, is better than I could have expected. You dont realize how much noise it makes until its no longer there.
My previous mouse was too loud with clicks and uncomfortable, this one remedies both and has so far been flawless. Great mouse so far (for right handed users)